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Ca2+signaling in dendritic spines

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
17
Issue
3
Identifiers
DOI: 10.1016/j.conb.2007.04.003
Disciplines
  • Chemistry
  • Medicine

Abstract

Recent studies have revealed that Ca 2+ signals evoked by action potentials or by synaptic activity within individual dendritic spines are regulated at multiple levels. Ca 2+ influx through glutamate receptors and voltage-sensitive Ca 2+ channels located on spines depends on the channel subunit composition, the activity of kinases and phosphatases, the local membrane potential and past patterns of activity. Furthermore, sources of spine Ca 2+ interact nonlinearly such that activation of one Ca 2+ channel can enhance or depress the activity of others. These studies have revealed that each spine is a complex and partitioned Ca 2+ signaling domain capable of autonomously regulating the electrical and biochemical consequences of synaptic activity.

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