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E-cadherin antagonizes transforming growth factor β1 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation.

Authors
  • Cho, Il Je
  • Kim, Young Woo
  • Han, Chang Yeob
  • Kim, Eun Hyun
  • Anderson, Richard A
  • Lee, Young Sok
  • Lee, Chang Ho
  • Hwang, Se Jin
  • Kim, Sang Geon
Type
Published Article
Journal
Hepatology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Dec 01, 2010
Volume
52
Issue
6
Pages
2053–2064
Identifiers
DOI: 10.1002/hep.23931
PMID: 20890948
Source
Medline
License
Unknown

Abstract

Our results demonstrate that ECAD inhibits Smad3/2 phosphorylation by recruiting RhoA to p120-ctn at the p120-ctn binding domain, whereas the loss of ECAD due to cadherin switching promotes the up-regulation of TGFβ1 and its target genes, and facilitates liver fibrosis.

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