E-cadherin antagonizes transforming growth factor β1 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation.
- Authors
- Type
- Published Article
- Journal
- Hepatology
- Publisher
- Wiley (John Wiley & Sons)
- Publication Date
- Dec 01, 2010
- Volume
- 52
- Issue
- 6
- Pages
- 2053–2064
- Identifiers
- DOI: 10.1002/hep.23931
- PMID: 20890948
- Source
- Medline
- License
- Unknown
Abstract
Our results demonstrate that ECAD inhibits Smad3/2 phosphorylation by recruiting RhoA to p120-ctn at the p120-ctn binding domain, whereas the loss of ECAD due to cadherin switching promotes the up-regulation of TGFβ1 and its target genes, and facilitates liver fibrosis.
