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Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex.

Authors
  • Yang, Fei1
  • Yang, Lingli1
  • Wataya-Kaneda, Mari2
  • Hasegawa, Junya3
  • Yoshimori, Tamotsu3
  • Tanemura, Atsushi1
  • Tsuruta, Daisuke4
  • Katayama, Ichiro1
  • 1 Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan. , (Japan)
  • 2 Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan. Electronic address: [email protected] , (Japan)
  • 3 Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan. , (Japan)
  • 4 Department of Dermatology, Graduate School of Medicine, Osaka City University, Osaka, Japan. , (Japan)
Type
Published Article
Journal
Journal of dermatological science
Publication Date
Nov 11, 2017
Identifiers
DOI: 10.1016/j.jdermsci.2017.11.002
PMID: 29146131
Source
Medline
Keywords
License
Unknown

Abstract

Our data demonstrate that melanocytes of patients with TSC display autophagic dysregulation, which thereby reduced pigmentation, serving as the basis for the hypomelanotic macules characteristic of TSC.

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