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Dyslipoproteinaemia, signal transduction, and angiogenesis.

Authors
Type
Published Article
Journal
European heart journal
Publication Date
Volume
14 Suppl I
Pages
198–200
Identifiers
PMID: 8293776
Source
Medline

Abstract

Hyperlipidaemic states are associated with endothelial cell dysfunction which may in part be related to the accumulation of toxic lipoprotein degradation products in artery walls. One effect of oxidized LDL and its products is to impair transmembrane signalling, a process that might alter responsiveness of endothelial cells to mitogens. Endothelial cell replication plays a pivotal role in the growth of pre-existing arterial channels and in the formation of new microvessels (angiogenesis). Experiments in intact rabbits indicate that endothelial replication associated with vascular growth is markedly impaired in the presence of hypercholesterolaemia, a defect that could play an important role in the pathophysiology of occlusive atherosclerotic disease.

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