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Dysbindin-1 and schizophrenia: from genetics to neuropathology

Authors
  • Michael J. Owen
  • Nigel M. Williams
  • Michael C. O’Donovan
Publisher
American Society for Clinical Investigation
Publication Date
May 01, 2004
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

The gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic neurons and is reduced at these locations in schizophrenia . Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia.

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