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DYNLRB1 is essential for dynein mediated transport and neuronal survival

Authors
  • Terenzio, Marco1, 2
  • Di Pizio, Agostina1
  • Rishal, Ida1
  • Marvaldi, Letizia1
  • Di Matteo, Pierluigi1
  • Kawaguchi, Riki3
  • Coppola, Giovanni3
  • Schiavo, Giampietro4, 5, 6
  • Fisher, Elizabeth M.C.4
  • Fainzilber, Mike1
  • 1 Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel
  • 2 Molecular Neuroscience Unit, Okinawa Institute of Science and Technology Graduate University, Kunigami-gun, Okinawa 904-0412, Japan
  • 3 Departments of Psychiatry and Neurology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA
  • 4 Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK
  • 5 UK Dementia Research Institute, University College London, London WC1E 6BT, UK
  • 6 Discoveries Centre for Regenerative and Precision Medicine, University College London Campus, London WC1N 3BG, UK
Type
Published Article
Journal
Neurobiology of Disease
Publisher
Elsevier
Publication Date
Jul 01, 2020
Volume
140
Identifiers
DOI: 10.1016/j.nbd.2020.104816
PMID: 32088381
PMCID: PMC7273200
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Depletion of DYNLRB1 impairs neurite outgrowth in sensory neurons. • Complete knockout of DYNLRB1 causes early embryonic lethality. • Specific repression of DYNLRB1 causes loss of proprioceptive neurons and impairs proprioception. • DYNLRB1 is required for effective axonal retrograde transport of lysosomes and signaling endosomes.

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