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Dynamics of success and failure in phage and antibiotic therapy in experimental infections.

Authors
Type
Published Article
Journal
BMC Microbiology
1471-2180
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
2
Pages
35–35
Identifiers
PMID: 12453306
Source
Medline
License
Unknown

Abstract

1) The Smith and Huggins phage and antibiotic therapy results are quantitatively and qualitatively robust. (2) Our RCA values reflect the microbiological efficacies of the different phages and of streptomycin in preventing mortality, and reflect the decline in their efficacy with a delay in treatment. These results show specifically that bacteria become refractory to treatment over the term of infection. (3) The K1-specific and non-specific phages had similar replication rates on bacteria grown in broth (based on the PRA), but the K1-specific phage had markedly greater replication rates in mouse serum.

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