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Dynamics of inflammatory markers in post-acute stroke patients undergoing rehabilitation.

Authors
  • Manolescu, Bogdan Nicolae
  • Berteanu, Mihai
  • Dumitru, Luminița
  • Dinu, Horațiu
  • Iliescu, Alina
  • Fărcășanu, Ileana Cornelia
  • Oprea, Eliza
  • Vlădoiu, Suzana
  • Popa, Oana
  • Ianăș, Olga
Type
Published Article
Journal
Inflammation
Publisher
Springer-Verlag
Publication Date
Dec 01, 2011
Volume
34
Issue
6
Pages
551–558
Identifiers
DOI: 10.1007/s10753-010-9262-8
PMID: 20882328
Source
Medline
License
Unknown

Abstract

Stroke is a pathological condition associated with an enhanced inflammatory response that has a multifactorial etiology. We evaluated the dynamic of plasma concentrations of IL-1α, IL-6, IL-8, TNF-α, soluble form of intercellular adhesion molecule 1, and lipoprotein (a) [Lp(a)] during the rehabilitation of post-acute stroke patients (n = 20), in parallel with control subjects (n = 24). Stroke patients had significantly increased concentrations of IL-6, TNF-α, and Lp(a) when compared to healthy controls. It was found that the changes in the IL-6, IL-8, and TNF-α concentrations associated with the pathological condition were statistically significant (χ2 = 4.81, p = 0.028, χ2 = 10.40, p = 0.005 and χ2 = 6.73, p = 0.034, respectively). The decrease of Lp(a) during the rehabilitation had statistical significance (p = 0.043), while the decrease of IL-1α had marginal significance (p = 0.071). IL-1α, TNF-α, and Lp(a) concentrations were significantly negatively correlated with the Barthel index values, suggesting that the decrease of these inflammatory markers was beneficial for patients' recovery.

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