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[Dynamics of the behavioral response and cortisole level caused by the combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation in mice under immobilization stress conditions].

Authors
  • Podsevatkin, V G
  • Kiriukhina, S V
  • Podsevatkin, D V
  • Podsevatkina, S V
  • Blinov, D S
Type
Published Article
Journal
Eksperimental'naia i klinicheskaia farmakologiia
Publication Date
Jan 01, 2008
Volume
71
Issue
1
Pages
22–25
Identifiers
PMID: 18365482
Source
Medline
License
Unknown

Abstract

Experiments on white mice under the model immobilization stress condition showed that a combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation (pathogenetic therapy) leads to optimization of the behavioral reactions, which is manifested by a decrease in the level of anxiety, increase in the locomotor and research activity, and normalization of the cortisole level. This effect is explained by a complex pharmacological action of all factors on the immune and endocrine mechanisms of the stress pathogenesis.

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