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Dynamic temporal and spatial regulation of the cdk inhibitor p57(kip2) during embryo morphogenesis.

Authors
Type
Published Article
Journal
Mechanisms of development
Publication Date
Volume
109
Issue
1
Pages
83–89
Identifiers
PMID: 11677056
Source
Medline

Abstract

The complete developmental expression pattern of the cyclin dependent kinase inhibitor (CDKI) p57(kip2) has not been reported, here we report a detailed study of the localization of p57(kip2) protein during mouse organogenesis. We show that p57(kip2) is coincident with key stages of differentiation of several organs, some but not all of which are affected in Beckwith-Weidermann syndrome, a human congenital syndrome characterized by foetal overgrowth and childhood tumours.

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