Affordable Access

deepdyve-link
Publisher Website

Dynamic single gold nanoparticle visualization by clinical intracoronary optical coherence tomography.

Authors
  • Hu, Jie1
  • Rivero, Fernando2
  • Torres, Rio Aguilar2
  • Loro Ramírez, Héctor3
  • Rodríguez, Emma Martín1, 4
  • Alfonso, Fernando2
  • García Solé, José1
  • Jaque, Daniel1, 4
  • 1 Fluorescence Imaging Group, Departamento de Física de Materiales, Instituto Nicolás Cabrera, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049, Madrid, Spain. , (Spain)
  • 2 Cardiology Department, Hospital Universitario de la Princesa, IIS-IP, Universidad Autónoma de Madrid, Madrid.
  • 3 Facultad de Ciencias, Universidad Nacional de Ingeniería, P.O. Box 31-139, Lima, Perú.
  • 4 Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Ramón y Cajal, 28034, Madrid, Spain. , (Spain)
Type
Published Article
Journal
Journal of Biophotonics
Publisher
Wiley (John Wiley & Sons)
Publication Date
May 01, 2017
Volume
10
Issue
5
Pages
674–682
Identifiers
DOI: 10.1002/jbio.201600062
PMID: 27273138
Source
Medline
Keywords
License
Unknown

Abstract

The potential use of Gold Nanoparticles (GNPs) as contrast agents for clinical intracoronary frequency domain Optical Coherence Tomography (OCT) is here explored. The OCT contrast enhancement caused by GNPs of different sizes and morphologies has been systematically investigated and correlated with their optical properties. Among the different GNPs commercially available with plasmon resonances close to the operating wavelength of intracoronary OCT (1.3 µm), Gold Nanoshells (GNSs) have provided the best OCT contrast due to their largest scattering cross section at this wavelength. Clinical intracoronary OCT catheters are here demonstrated to be capable of three dimensional visualization and real-time tracking of individual GNSs. Results here included open an avenue to novel application of intravascular clinical OCT in combination with GNPs, such as real time evaluation of intravascular obstructions or pressure gradients.

Report this publication

Statistics

Seen <100 times