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Dynamic Sensitivity of Corneal TRPM8 Receptors to Menthol Instillation in Dry Eye Versus Normal Subjects.

Authors
  • Corcoran, Peter1
  • Hollander, David A1, 2
  • Ousler, George W 3rd1
  • Angjeli, Endri1
  • Rimmer, David1
  • Lane, Keith1
  • Abelson, Mark B1, 3
  • 1 1 Ora, Inc. , Andover, Massachusetts.
  • 2 2 Jules Stein Eye Institute, University of Southern California , Los Angeles, California.
  • 3 3 Department of Ophthalmology, Harvard Medical School , Boston, Massachusetts.
Type
Published Article
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Publication Date
Nov 01, 2017
Volume
33
Issue
9
Pages
686–692
Identifiers
DOI: 10.1089/jop.2017.0050
PMID: 28933582
Source
Medline
Keywords
License
Unknown

Abstract

DED subjects had greater sensitivity to cold than normal subjects. DED duration, and not age, was critical to cooling sensitivity. The finding that cooling scores were higher in subjects with DED for less than 10 years compared to more than 10 years suggests that corneal cold receptor sensitivity decreases as the duration of DED increases.

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