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A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals

Authors
  • Demetriou, Philippos1
  • Abu-Shah, Enas1, 1
  • Valvo, Salvatore1
  • McCuaig, Sarah1
  • Mayya, Viveka1, 2
  • Kvalvaag, Audun1
  • Starkey, Thomas3
  • Korobchevskaya, Kseniya1
  • Lee, Lennard Y. W.3
  • Friedrich, Matthias1
  • Mann, Elizabeth1
  • Kutuzov, Mikhail A.1
  • Morotti, Matteo1
  • Wietek, Nina1
  • Rada, Heather1
  • Yusuf, Shamsideen1
  • Afrose, Jehan1, 2, 4
  • Siokis, Anastasios5
  • Allan, Philip6
  • Ambrose, Timothy6
  • And 23 more
  • 1 University of Oxford, Oxford, UK , Oxford (United Kingdom)
  • 2 New York University of School of Medicine, New York, NY, USA , New York (United States)
  • 3 University of Birmingham, Birmingham, United Kingdom , Birmingham (United Kingdom)
  • 4 CUNY Hunter College, New York, NY, USA , New York (United States)
  • 5 Helmholtz Centre for Infection Research, Braunschweig, Germany , Braunschweig (Germany)
  • 6 University of Oxford, John Radcliffe Hospital, Oxford, UK , Oxford (United Kingdom)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Sep 14, 2020
Volume
21
Issue
10
Pages
1232–1243
Identifiers
DOI: 10.1038/s41590-020-0770-x
Source
Springer Nature
License
Yellow

Abstract

The adhesion receptor CD2 plays an important role in the full activation of T cells. Dustin and colleagues show that CD2 occupies a region in the periphery of the immunological synapse where it amplifies cognate antigen signals, whereas the presence of PD-1 disrupts this effect.

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