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Durable control of Hepatitis C through interferon-free antiviral combination therapy immediately prior to allogeneic hematopoietic stem cell transplantation.

Authors
  • Rauwolf, Kerstin1
  • Herbrüggen, Heidi1
  • Zöllner, Stefan1
  • Thorer, Heike1
  • Makarova, Olga1
  • Kaiser, Thomas2
  • Pettke, Aleksandra3
  • Rossig, Claudia1
  • Burkhardt, Birgit1
  • Groll, Andreas H1
  • 1 Department of Pediatric Hematology/Oncology, Münster, Federal Republic of Germany. , (Germany)
  • 2 Department of General Pediatrics, University Children's Hospital Münster, Münster, Federal Republic of Germany. , (Germany)
  • 3 Department of Medical Microbiology, University Hospital Münster, Münster, Federal Republic of Germany. , (Germany)
Type
Published Article
Journal
Journal of Viral Hepatitis
Publisher
Wiley (Blackwell Publishing)
Publication Date
Dec 05, 2018
Identifiers
DOI: 10.1111/jvh.13046
PMID: 30516856
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Chronic hepatitis C virus (HCV) infection carries increased risks for morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) but has become curable through the advent of directly acting antiviral compounds. Current guidelines of the American Society for Blood and Marrow Transplantation (ASBMT) recommend that HCV-infected HSCT candidates preferably start and complete therapy prior to transplant. However, this is often not feasible due to time constraints or treatment limiting comorbidities, conditions and treatments. For these reasons, data on the safety of antiviral treatment, its efficacy to achieve durable eradication of the virus until full immune recovery, and late effects of former HCV infection in patients receiving HSCT are unknown. Here we report the course of two pediatric patients with chronic HCV infection who received a full course of directly acting antivirals prior to allogeneic HSCT and achieved and maintained viral eradication throughout transplantation until complete immune recovery. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

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