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Duodenal alkalinization releases secretin and vasoactive intestinal polypeptide and stimulates exocrine pancreatic secretion in the anesthetized rat.

Authors
  • García, L J
  • Minguela, A
  • Montero, A
  • Calvo, J J
  • López, M A
Type
Published Article
Journal
Digestion
Publication Date
Jan 01, 1990
Volume
47
Issue
4
Pages
215–225
Identifiers
PMID: 1966046
Source
Medline
License
Unknown

Abstract

The effect of various intraduodenal alkaline solutions (0.1 M NaHCO3, 0.1 M Na2CO3 and 0.025 M NaOH) on exocrine pancreatic secretion and the release of two peptides, secretin and vasoactive intestinal polypeptide, was studied in anesthetized rats. The flow rate of the pancreatic juice was stimulated up to a maximum of 179, 158 and 180% and the protein output up to 181, 131 and 162% (compared with basal) after duodenal perfusion of, respectively, 0.1 M NaHCO3, 0.1 M Na2CO3 and 0.025 M NaOH. Maximum increases in portal plasma secretin concentrations of 143, 146 and 190% and maximum increases in VIP of 116, 155 and 147% after, respectively, intraduodenal 0.1 M NaHCO3, 0.1 M Na2CO3, and 0.025 M NaOH were found. In conclusion duodenal alkalinization in the rat produces a pancreatic exocrine secretory response that may be partially ascribed to the effect of secretin and VIP.

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