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Duclauxin Derivatives From Fungi and Their Biological Activities

Authors
  • Shahid, Hamza1
  • Cai, Teng1
  • Wang, Yuyang1
  • Zheng, Caiqing1
  • Yang, Yuting1
  • Mao, Ziling1
  • Ding, Ping2
  • Shan, Tijiang1
  • 1 Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou , (China)
  • 2 School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou , (China)
Type
Published Article
Journal
Frontiers in Microbiology
Publisher
Frontiers Media SA
Publication Date
Dec 22, 2021
Volume
12
Identifiers
DOI: 10.3389/fmicb.2021.766440
Source
Frontiers
Keywords
Disciplines
  • Microbiology
  • Review
License
Green

Abstract

Duclauxin is a heptacyclic oligophenalenone dimer consisting of an isocoumarin and a dihydroisocoumarin unit. These two tricyclic moieties are joined by a cyclopentane ring to form a unique hinge or castanets-like structure. Duclauxin is effective against numerous tumor cell lines because it prevents adenosine triphosphate (ATP) synthesis by inhibiting mitochondrial respiration. There are about 36 reported natural duclauxin analogs mainly produced by 9 Penicillium and Talaromyces species (T. duclauxii, T. aculeatus, T. stipitatus, T. bacillisporus, T. verruculosus, T. macrosporus, P. herquei, P. manginii, and Talaromyces sp.). These metabolites exhibit remarkable biological activities, including antitumor, enzyme inhibition, and antimicrobial, showing tremendous potential in agricultural and medical applications. This review highlights the chemical structures and biological activities of fungal duclauxins, together with biosynthesis, absolute configuration, and mode of action for important duclauxins. Furthermore, phylogenetic analysis and correct names of Penicillium and Talaromyces species producing duclauxins are presented in this review.

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