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Dual-pH/Magnetic-Field-Controlled Drug Delivery Systems Based on Fe3 O4 @SiO2 -Incorporated Salecan Graft Copolymer Composite Hydrogels.

Authors
  • Hu, Xinyu1
  • Wang, Yongmei1
  • Zhang, Liangliang1
  • Xu, Man1
  • Zhang, Jianfa2
  • Dong, Wei2
  • 1 Institute of Chemical Industry of Forestry Products, CAF, Nanjing, 210042, China. , (China)
  • 2 Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China. , (China)
Type
Published Article
Journal
ChemMedChem
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 09, 2017
Volume
12
Issue
19
Pages
1600–1609
Identifiers
DOI: 10.1002/cmdc.201700428
PMID: 28857472
Source
Medline
Keywords
License
Unknown

Abstract

Salecan is a water-soluble extracellular β-glucan and has excellent physicochemical and biological properties for hydrogel preparation. In this study, a new pH/magnetic field dual-responsive hydrogel was prepared by the graft copolymerization of salecan with 4-pentenoic acid (PA) and N-hydroxyethylacrylamide (HEAA) in the presence of Fe3 O4 @SiO2 nanoparticles for doxorubicin hydrochloride (DOX) release. Integration of Fe3 O4 @SiO2 nanoparticles in salecan-g-poly(PA-co-HEAA) copolymers afforded magnetic sensitivity to the original material. DOX-loaded hydrogels exhibited a clear capacity for pH/magnetic field dual-responsive controlled drug release. Lowering the pH to acidic conditions or introducing an external magnetic field caused an enhancement in DOX release. This salecan-g-poly(PA-co-HEAA)/Fe3 O4 @SiO2 composite hydrogel is a promising drug carrier for magnetically targeted drug delivery with enhanced DOX cytotoxicity against A549 cells.

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