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Dual-trait selection for ethanol consumption and withdrawal: genetic and transcriptional network effects.

Authors
Type
Published Article
Journal
Alcoholism Clinical and Experimental Research
1530-0277
Publisher
Wiley Blackwell (Blackwell Publishing)
Publication Date
Volume
38
Issue
12
Pages
2915–2924
Identifiers
DOI: 10.1111/acer.12574
PMID: 25581648
Source
Medline
Keywords
License
Unknown

Abstract

Marked effects of selection on expression and network structure were detected. QTLs overlapping with differentially expressed genes on Chr 2 (distal) and 4 suggest that these are cis-eQTLs (Chr 2: Kif3b, Kcnq2; Chr 4: Mpdz, Snapc3). Other QTLs identified were on Chr 2 (proximal), 9, and 12. Network results point to involvement of kinase-related mechanisms and outline the need for further efforts such as interrogation of noncoding RNAs.

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