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Dual-specificity phosphatases 2: surprising positive effect at the molecular level and a potential biomarker of diseases.

Authors
  • W, Wei
  • Y, Jiao
  • A, Postlethwaite
  • Josh Stuart
  • Y, Wang
  • D, Sun
  • W, Gu
Type
Published Article
Journal
Genes and Immunity
Publisher
Springer Nature
Volume
14
Issue
1
Pages
1–6
Identifiers
DOI: 10.1038/gene.2012.54
Source
UCSC Cancer biomedical-ucsc
License
Unknown

Abstract

Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target.

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