Affordable Access

deepdyve-link
Publisher Website

The Dual Roles of the Atypical Protein Kinase Cs in Cancer.

Authors
  • Reina-Campos, Miguel1
  • Diaz-Meco, Maria T1
  • Moscat, Jorge2
  • 1 Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.
  • 2 Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: [email protected]
Type
Published Article
Journal
Cancer cell
Publication Date
Sep 16, 2019
Volume
36
Issue
3
Pages
218–235
Identifiers
DOI: 10.1016/j.ccell.2019.07.010
PMID: 31474570
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered fundamental regulators of tumorigenesis. However, the specific separation of functions that determine their different roles in cancer is still being unraveled. Both aPKCs have pleiotropic context-dependent functions that can translate into tumor-promoter or -suppressive functions. Here, we review early and more recent literature to discuss how the different tumor types, and their microenvironments, might account for the selective signaling of each aPKC isotype. This is of clinical relevance because a better understanding of the roles of these kinases is essential for the design of new anti-cancer treatments. Copyright © 2019 Elsevier Inc. All rights reserved.

Report this publication

Statistics

Seen <100 times