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The dual role of autonomously replicating sequences as origins of replication and as silencers

Authors
  • Rehman, Muhammad Attiq1, 2
  • Yankulov, Krassimir1
  • 1 University of Guelph, Department of Molecular and Cellular Biology, Guelph, ON, N1G 2W1, Canada , Guelph (Canada)
  • 2 National Institute of Child Health and Human Development, NIH, Laboratory of Gene Regulation and Development, Bethesda, MD, 20892, USA , Bethesda (United States)
Type
Published Article
Journal
Current Genetics
Publisher
Springer-Verlag
Publication Date
Jul 26, 2009
Volume
55
Issue
4
Pages
357–363
Identifiers
DOI: 10.1007/s00294-009-0265-7
Source
Springer Nature
Keywords
License
Yellow

Abstract

Autonomously replicating sequences (ARSs) in Saccharomyces cerevisiae have been extensively characterized as both origins of DNA replication and as chromatin repressors/silencers. It has been conclusively shown that the origin and the silencer activities of ARS are substantially, but not entirely interchangeable and that they are modulated by position effects and chromatin environment. It remains unclear how these two quite divergent functions of ARS co-exist. This perspective focuses on recent advances, which have shown that slight differences in ARSs can modulate their affinity for origin recognition complex and their activity as silencers or origins.

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