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The Dual Regulatory Role of MiR-181a in Breast Cancer.

Authors
  • Yang, Chun1
  • Tabatabaei, Seyed Nasrollah1
  • Ruan, Xiangyan2
  • Hardy, Pierre1
  • 1 Departments of Pediatrics and Pharmacology, University of Montreal, Montreal, Québec, Canada. , (Canada)
  • 2 Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. , (China)
Type
Published Article
Journal
Cellular Physiology and Biochemistry
Publisher
S. Karger AG
Publication Date
Jan 01, 2017
Volume
44
Issue
3
Pages
843–856
Identifiers
DOI: 10.1159/000485351
PMID: 29176320
Source
Medline
Keywords
License
Unknown

Abstract

MicroRNAs (miRNAs) are a family of highly conserved noncoding single-stranded RNA molecules of 21 to 25 nucleotides. miRNAs silence their cognate target genes at the post-transcriptional level and have been shown to have important roles in oncogenesis, invasion, and metastasis via epigenetic post-transcriptional gene regulation. Recent evidence indicates that the expression of miR-181a is altered in breast tumor tissue and in the serum of patients with breast cancer. However, there are several contradicting findings that challenge the biological significance of miR-181a in tumor development and metastasis. In fact, some studies have implicated miR-181a in regulating breast cancer gene expression. Here we summarize the current literature demonstrating established links between miR-181a and human breast cancer with a focus on recently identified mechanisms of action. This review also aims to explore the potential of miR-181a as a diagnostic and/or prognostic biomarker for breast cancer and to discuss the contradicting data regarding its targeting therapeutics and the associated challenges.

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