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Dual rearrangement of immunoglobulin and T-cell receptor gene in a case of T-cell hairy-cell leukemia.

Authors
  • Palumbo, A P
  • Corradini, P
  • Battaglio, S
  • Omedè, P
  • Coda, R
  • Boccadoro, M
  • Pileri, A
Type
Published Article
Journal
European journal of haematology
Publication Date
Feb 01, 1991
Volume
46
Issue
2
Pages
71–76
Identifiers
PMID: 1847340
Source
Medline
License
Unknown

Abstract

We report a case of T-cell hairy-cell leukemia with a dual rearrangement of Ig- and T-cell receptor genes. The cytochemical, transmission electron microscopy, and surface antigens data (CD3+, CD8+, CD11+, HLA-DR+, CD19-, CD20-) were consistent with a T-cell hairy-cell leukemia. Molecular analysis according to Southern revealed a dual rearrangement of immunoglobulin heavy-chain (JH) and T-cell receptor beta (TcR beta) chain genes. Our findings suggest that the coexistence of JH and TcR gene rearrangements, frequently detected in acute leukemia, may also be observed in hematologic malignancies derived from more differentiated cells.

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