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Dual-photon absorptiometry: comparison of bone mineral and soft tissue mass measurements in vivo with established methods.

Authors
  • Heymsfield, S B
  • Wang, J
  • Heshka, S
  • Kehayias, J J
  • Pierson, R N
Type
Published Article
Journal
The American journal of clinical nutrition
Publication Date
Jun 01, 1989
Volume
49
Issue
6
Pages
1283–1289
Identifiers
PMID: 2729167
Source
Medline
License
Unknown

Abstract

This study extended initial observations that indicated the potential of dualphoton absorptiometry (DPA) to measure total-body bone mineral (TBBM) and fat in vivo. DPA-derived TBBM and fat were compared with established methods in 13 subjects (aged 24-94 y) who underwent measurement of body density (Db), total-body water (TBW), potassium (TBK), calcium (TBCa, delayed-gamma neutron activation), and nitrogen (prompt-gamma neutron activation). TBBM was highly correlated with TBCa (r = 0.95, p less than 0.001) and the slope of TBCa vs TBBM (0.34) was similar to Ca content of ashed skeleton (0.34-0.38). DPA-measured fat (means +/- SD, 16.7 +/- 4.9 kg) correlated significantly (r = 0.79-0.94; p less than 0.01-0.001) with fat established by Db (16.3 +/- 5.4 kg), TBW (16.0 +/- 4.3 kg), TBK (17.7 +/- 4.6 kg), combined TBW-neutron activation (17.6 +/- 5.9 kg), and means of all four methods (16.9 +/- 4.8 kg). DPA thus offers a new opportunity to study human skeleton in vivo and to quantify fat by a method independent from the classical assumption that bone represents a fixed fraction of fat-free body mass.

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