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Dual-modal imaging and photodynamic therapy using upconversion nanoparticles for tumor cells.

Authors
  • Yang, Chunna
  • Liu, Qiuling
  • He, Dacheng
  • Na, Na
  • Zhao, Yunling
  • Ouyang, Jin
Type
Published Article
Journal
The Analyst
Publisher
The Royal Society of Chemistry
Publication Date
Dec 21, 2014
Volume
139
Issue
24
Pages
6414–6420
Identifiers
DOI: 10.1039/c4an01642d
PMID: 25327945
Source
Medline
License
Unknown

Abstract

Here we synthesized silica-coated NaYF4:Yb,[email protected] nanoparticles with hypocrellin photosensitizers covalently incorporated inside the silica shells, combining dual modal imaging and photodynamic therapy (PDT) functions together. Under excitation at 980 nm, the tumor-targeting specificity of the as-prepared nanomaterials efficiently enhanced as folic acid (FA) was conjugated. The internalization of [email protected]@hypocrellin A-FA in HeLa cells and HEK-293 cells was observed by confocal microscopy and in vitro magnetic resonance imaging (MRI), which demonstrated that the as-prepared nanocomposites have the ability to target folate receptor (FR) (+) cells. Moreover, magnetic resonance (MR) measurements also demonstrated that the as-prepared nanocomposites could be used as a contrast agent for MRI. All these results showed the feasibility and potential of the as-prepared nanocomposites for simultaneous imaging and PDT application.

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