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Dual effects of alpha-synuclein on neurotoxicity induced by low dosage of rotenone are dependent on exposure time in dopaminergic neuroblastoma cells.

Authors
  • Lu, Lingling
  • Gu, Li
  • Liang, Yuan
  • Sun, Xiaohong
  • Duan, Chunli
  • Yang, Hui
Type
Published Article
Journal
Science China. Life sciences
Publication Date
May 01, 2010
Volume
53
Issue
5
Pages
590–597
Identifiers
DOI: 10.1007/s11427-010-0104-6
PMID: 20596942
Source
Medline
License
Unknown

Abstract

This study was designed to investigate the effects of alpha-synuclein on toxicity induced by long-term exposure to relatively low concentrations of rotenone. Compared with the control groups, the inhibition of cell viability which overexpressed alpha-synuclein (SH-SY5Y-Syn) improved after 1 and 2 weeks of rotenone treatment. The complex I activity was greater and the mitochondrial membrane swelling intensity was reduced after 1 and 2 weeks of treatment, which indicated that alpha-synuclein, at least in part, resists the rotenone-induced oxidative stress. The results indicate that alpha-synuclein has a dual effect on toxicity of rotenone according to exposure time in human SH-SY5Y cells.

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