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Dual effect of angiotensin-converting enzyme inhibition on angiogenesis in type 1 diabetic mice.

Authors
  • Ebrahimian, Téni G
  • Tamarat, Radia
  • Clergue, Michel
  • Duriez, Micheline
  • Levy, Bernard I
  • Silvestre, Jean-Sébastien
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Jan 01, 2005
Volume
25
Issue
1
Pages
65–70
Identifiers
PMID: 15528473
Source
Medline
License
Unknown

Abstract

ACE inhibition improved neovascularization in the diabetic ischemic leg through activation of bradykinin signaling, whereas it reduced vessel growth in the diabetic retina through inhibition of overacting Ang II pathway.

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