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[Drug release mechanism of famotidine time-controlled release pellets].

Authors
Type
Published Article
Journal
Yao xue xue bao = Acta pharmaceutica Sinica
Publication Date
Volume
41
Issue
9
Pages
873–877
Identifiers
PMID: 17111836
Source
Medline
License
Unknown

Abstract

The lag time of famotidine time-controlled release pellets is induced by the hydrophobicity of the film. After water dissolve the organic acid, the dissociated and undissociated forms of succinic acid interact with the film through different ways. These interactions can change the structure of the film. Therefore the permeability of the film will be improved markedly.

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