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Drug Interactions between Antimicrobial and Immunosuppressive Agents in Solid Organ Transplant Recipients

Authors
  • Bhagat, Vikas1
  • Pandit, Rahul A2
  • Ambapurkar, Shwetha3
  • Sengar, Manju4
  • Kulkarni, Atul P
  • 1 Department of Critical Care Medicine, Aster Hospital, Dubai, UAE
  • 2 Fortis Hospital, Mumbai, Maharashtra, India
  • 3 Department of Pharmacology, Fortis Hospital, Mumbai, Maharashtra, India
  • 4 Department of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India
Type
Published Article
Journal
Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine
Publisher
Jaypee Brothers Medical Publishers
Publication Date
Jan 01, 2021
Volume
25
Issue
1
Pages
67–76
Identifiers
DOI: 10.5005/jp-journals-10071-23439
PMID: 33603305
PMCID: PMC7874296
Source
PubMed Central
Keywords
License
Green

Abstract

The number of allogeneic solid organ and bone marrow transplants is increasing all over the world. To prevent transplant rejection and treat acute rejection of transplant, immunosuppressant drugs are used. The outcomes of solid organ transplants have dramatically improved over last 30 years, due to availability of multiple immunosuppressive agents, with varied mechanisms of action. The use of intense immunosuppression makes the individual having undergone solid organ transplant at the risk of several serious infections, which may prove fatal. To prevent and treat these infections (when they occur), patients are often given antimicrobial prophylaxis and therapy. The use of antimicrobials can interfere with the metabolism of the immunosuppressants, and may put the patient at risk of developing severe adverse effects due to unwanted increase or decrease in the serum levels of immunosuppressive agents. Knowledge of these interactions is essential for successful management of solid organ transplant patients. We therefore decided to review the literature and present the interactions that commonly occur between these two life-saving groups of drugs. How to cite this article: Bhagat V, Pandit RA, Ambapurkar S, Sengar M, Kulkarni AP. Drug Interactions between Antimicrobial and Immunosuppressive Agents in Solid Organ Transplant Recipients. Indian J Crit Care Med 2021;25(1):67–76.

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