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[Drug-induced exudative erythema multiforme major with a chronic progressive course and bilateral blindness. Clinical and immunohistologic follow-up].

Authors
  • Thiel, H J
  • Richter, U
  • Pleyer, U
  • Zierhut, M
  • Steuhl, K P
Type
Published Article
Journal
Klinische Monatsblätter für Augenheilkunde
Publication Date
Aug 01, 1990
Volume
197
Issue
2
Pages
142–149
Identifiers
PMID: 2147046
Source
Medline
License
Unknown

Abstract

A 24-year-old male patient who had been received Fansidar developed exudative erythema multiforme major with massive involvement of the skin, mucous membranes, and both eyes. The chronic inflammation led to proliferation of the conjunctiva, with keratinization of the ocular surface and corneal vascularization. The final result was comparable to cicatricial pemphigoid, with blindness of both eyes. In histological sections, massive lympho-plasma-cellular infiltration with circumscribed perivasculitis was seen. The lymphocyte transformation test was still positive 18 months after onset of the disease. Class II antigens were evident in some of the conjunctival biopsies.

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