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Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation.

Authors
  • Matsa, Elena1
  • Rajamohan, Divya
  • Dick, Emily
  • Young, Lorraine
  • Mellor, Ian
  • Staniforth, Andrew
  • Denning, Chris
  • 1 Wolfson Centre for Stem Cells, Tissue Engineering & Modelling, University of Nottingham, Nottingham NG7 2RD, UK.
Type
Published Article
Journal
European Heart Journal
Publisher
Oxford University Press
Publication Date
April 2011
Volume
32
Issue
8
Pages
952–962
Identifiers
DOI: 10.1093/eurheartj/ehr073
PMID: 21367833
Source
Medline
License
Unknown

Abstract

Findings from this paper demonstrate that patient LQT2-hiPSC cardiomyocytes respond appropriately to clinically relevant pharmacology and will be a valuable human in vitro model for testing experimental drug combinations.

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