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Drosophila strain specific response to cisplatin neurotoxicity.

Authors
  • Groen, Christopher M1
  • Podratz, Jewel L1
  • Treb, Kevin2
  • Windebank, Anthony J1
  • 1 a Department of Neurology , Mayo Clinic , Rochester , MN , USA.
  • 2 b Department of Medical Physics , University of Wisconsin , Madison , WI , USA.
Type
Published Article
Journal
Fly
Publisher
Landes Bioscience
Publication Date
Jan 01, 2018
Volume
12
Issue
3-4
Pages
174–182
Identifiers
DOI: 10.1080/19336934.2019.1565257
PMID: 30668272
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Drosophila melanogaster has recently been developed as a simple, in vivo, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell specific responses seen in humans. Cisplatin induces climbing deficiencies and loss of fertility in a dose dependent manner. Drosophila sensitivity to cisplatin in both cell types is affected by genetic background. We show that mutation or RNAi-based knockdown of genes known to be associated with CIPN incidence in humans affect sensitivity of flies to CIPN. Drosophila is a promising model with which to study the effect of genetics on sensitivity to CIPN.

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