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Drosophila Sidekick is required in developing photoreceptors to enable visual motion detection.

Authors
  • Astigarraga, Sergio1
  • Douthit, Jessica1
  • Tarnogorska, Dorota2
  • Creamer, Matthew S3
  • Mano, Omer4
  • Clark, Damon A3
  • Meinertzhagen, Ian A2
  • Treisman, Jessica E5
  • 1 Skirball Institute for Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
  • 2 Department of Psychology and Neuroscience, Life Sciences Centre, Dalhousie University, 1355 Oxford Street, Halifax, NS B3H 4R2, Canada. , (Canada)
  • 3 Interdepartmental Neuroscience Program, Yale University, Kline Biology Tower Room 224, 219 Whitney Avenue, New Haven, CT 06511, USA.
  • 4 Department of Molecular, Cellular and Developmental Biology, Yale University, Kline Biology Tower Room 224, 219 Whitney Avenue, New Haven, CT 06511, USA.
  • 5 Skirball Institute for Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA [email protected]
Type
Published Article
Journal
Development
Publisher
The Company of Biologists
Publication Date
Feb 05, 2018
Volume
145
Issue
3
Identifiers
DOI: 10.1242/dev.158246
PMID: 29361567
Source
Medline
Keywords
License
Unknown

Abstract

The assembly of functional neuronal circuits requires growth cones to extend in defined directions and recognize the correct synaptic partners. Homophilic adhesion between vertebrate Sidekick proteins promotes synapse formation between retinal neurons involved in visual motion detection. We show here that Drosophila Sidekick accumulates in specific synaptic layers of the developing motion detection circuit and is necessary for normal optomotor behavior. Sidekick is required in photoreceptors, but not in their target lamina neurons, to promote the alignment of lamina neurons into columns and subsequent sorting of photoreceptor axons into synaptic modules based on their precise spatial orientation. Sidekick is also localized to the dendrites of the direction-selective T4 and T5 cells, and is expressed in some of their presynaptic partners. In contrast to its vertebrate homologs, Sidekick is not essential for T4 and T5 to direct their dendrites to the appropriate layers or to receive synaptic contacts. These results illustrate a conserved requirement for Sidekick proteins in establishing visual motion detection circuits that is achieved through distinct cellular mechanisms in Drosophila and vertebrates.

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