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The DREAM complex promotes gene body H2A.Z for target repression.

Authors
  • Latorre, Isabel1
  • Chesney, Michael A1
  • Garrigues, Jacob M2
  • Stempor, Przemyslaw1
  • Appert, Alex1
  • Francesconi, Mirko3
  • Strome, Susan2
  • Ahringer, Julie4
  • 1 The Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom; , (United Kingdom)
  • 2 Molecular, Cell, and Developmental Biology, University of California at Santa Cruz, Santa Cruz, California 95064, USA;
  • 3 EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain. , (Spain)
  • 4 The Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom; [email protected]. , (United Kingdom)
Type
Published Article
Journal
Genes & development
Publication Date
Mar 01, 2015
Volume
29
Issue
5
Pages
495–500
Identifiers
DOI: 10.1101/gad.255810.114
PMID: 25737279
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of lin-35, the sole p130/Rb-like gene in C. elegans, DREAM targets have reduced gene body HTZ-1/H2A.Z and increased expression. Consistent with a repressive role for gene body H2A.Z, many DREAM targets are up-regulated in htz-1/H2A.Z mutants. Our results indicate that the DREAM complex facilitates high gene body HTZ-1/H2A.Z, which plays a role in target gene repression. © 2015 Latorre et al.; Published by Cold Spring Harbor Laboratory Press.

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