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Dramatic post-cardiotomy outcome, due to severe anaphylactic reaction to protamine.

Authors
Type
Published Article
Journal
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Publication Date
Volume
24
Issue
2
Pages
325–327
Identifiers
PMID: 12895638
Source
Medline

Abstract

Immunologic reactions to protamine sulfate during cardiac surgery are very rare. The frequency and outcome of such adverse reactions is unclear. We report a case of lethal anaphylactic reaction to protamine that occurred in a non-diabetic patient following the uneventful replacement of the ascending aorta. We also briefly review the mechanisms of this adverse reaction and emit some considerations on the management of this situation.

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