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Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease.

Authors
  • Boyle, J R
  • McDermott, E
  • Crowther, M
  • Wills, A D
  • Bell, P R
  • Thompson, M M
Type
Published Article
Journal
Journal of Vascular Surgery
Publisher
Elsevier
Publication Date
Feb 01, 1998
Volume
27
Issue
2
Pages
354–361
Identifiers
PMID: 9510291
Source
Medline
License
Unknown

Abstract

Therapeutic ranges of doxycycline significantly inhibited elastin degradation and MMP-9 production within aortic organ cultures. These data suggest that doxycycline may have a potential application in reducing the growth rates of small abdominal aortic aneurysms.

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