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Doxorubicin and Indocyanine Green Loaded Hybrid Bicelles for Fluorescence Imaging Guided Synergetic Chemo/Photothermal Therapy.

Authors
  • Lin, Li1
  • Liang, Xiaolong1
  • Xu, Yunxue1
  • Yang, Yongbo1
  • Li, Xiaoda1
  • Dai, Zhifei1
  • 1 Department of Biomedical Engineering, College of Engineering, Peking University , Beijing 100871, China. , (China)
Type
Published Article
Journal
Bioconjugate Chemistry
Publisher
American Chemical Society
Publication Date
Sep 20, 2017
Volume
28
Issue
9
Pages
2410–2419
Identifiers
DOI: 10.1021/acs.bioconjchem.7b00407
PMID: 28810733
Source
Medline
License
Unknown

Abstract

Hybrid bicelles have been demonstrated to have great potential for hydrophobic drug delivery. Herein, we report a near-infrared light-driven, temperature-sensitive hybrid bicelles co-encapsulating hydrophobic doxorubicin (DOX) and indocyanine green (ICG) (DOX/[email protected]). Encapsulation of ICG into the lipid bilayer membrane of DOX/[email protected] results in higher photostability than free ICG. DOX/[email protected] exhibited temperature-regulated drug release behavior and significant photothermal cytotoxicity. After tail vein injection, such discotic nanoparticles of DOX/[email protected] were found to accumulate selectively at the tumor site and act as an efficient probe to enhance fluorescence imaging greatly. The in vivo experiments showed that the DOX/[email protected] chemo- and photothermal combination therapy was more cytotoxic to tumor cells than the photothermal treatment or the chemotherapy alone due to the synergistic effect, reducing the occurrence of tumor metastasis. Therefore, DOX/[email protected] can act as a powerful nanotheranostic agent for chemo/photothermal therapy of cancer under the guidance of near-infrared fluorescence imaging.

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