Affordable Access

Doxapram inhibits the in vitro oxidation of hexobarbital.

Authors
Type
Published Article
Journal
Research communications in chemical pathology and pharmacology
Publication Date
Volume
72
Issue
3
Pages
371–374
Identifiers
PMID: 1719592
Source
Medline
License
Unknown

Abstract

The effect of doxapram on the mouse liver microsomal hexobarbital metabolism in vitro was studied. Doxapram inhibited hexobarbital oxidase in a competitive manner, with inhibition constants between 2 and 10 mM. Doxapram induced a reverse type I spectral change with a spectral dissociation constant of about 0.1 microM. These results indicate that doxaprame is an inhibitor of microsomal drug metabolism in the mouse.

Statistics

Seen <100 times