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Downregulation of Keap1 Confers Features of a Fasted Metabolic State

Authors
  • Knatko, Elena V.1
  • Tatham, Michael H.2
  • Zhang, Ying1
  • Castro, Cecilia3
  • Higgins, Maureen1
  • Dayalan Naidu, Sharadha1
  • Leonardi, Chiara1
  • de la Vega, Laureano1
  • Honda, Tadashi4
  • Griffin, Julian L.3, 5
  • Hay, Ronald T.2
  • Dinkova-Kostova, Albena T.1, 6
  • 1 Jacqui Wood Cancer Centre, Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, Scotland DD1 9SY, UK
  • 2 Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK
  • 3 Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1QW, UK
  • 4 Department of Chemistry and Institute of Chemical Biology & Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400, USA
  • 5 Section of Biomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, UK
  • 6 Department of Pharmacology and Molecular Sciences and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Type
Published Article
Journal
iScience
Publisher
Elsevier
Publication Date
Oct 06, 2020
Volume
23
Issue
10
Identifiers
DOI: 10.1016/j.isci.2020.101638
PMID: 33103077
PMCID: PMC7575887
Source
PubMed Central
Keywords
License
Unknown

Abstract

Human Metabolism; Molecular Biology; Omics

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