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Downregulated MicroRNA-195 in the Bicuspid Aortic Valve Promotes Calcification of Valve Interstitial Cells via Targeting SMAD7.

Authors
  • Du, Junjie1
  • Zheng, Rui1
  • Xiao, Feng2
  • Zhang, Shuai1
  • He, Keshuai1
  • Zhang, Junjie1
  • Shao, Yongfeng1
  • 1 Department of Cardiovascular Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. , (China)
  • 2 Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China. , (China)
Type
Published Article
Journal
Cellular Physiology and Biochemistry
Publisher
S. Karger AG
Publication Date
Jan 01, 2017
Volume
44
Issue
3
Pages
884–896
Identifiers
DOI: 10.1159/000485356
PMID: 29176317
Source
Medline
Keywords
License
Unknown

Abstract

miR-195 is downregulated more in stenotic BAV than TAV in this study. The downregulation of miR-195 is associated with valvular calcification via targeting SMAD7, which promotes the remodeling of the extracellular matrix.

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