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Down-regulation of type I protein kinase A by transfection of human breast cancer cells with an epidermal growth factor receptor antisense expression vector.

Authors
  • Ciardiello, F
  • Dixit, M
  • di Isernia, G
  • Damiano, V
  • Bianco, R
  • Bianco, A R
  • Arteaga, C L
  • Tortora, G
Type
Published Article
Journal
Breast cancer research and treatment
Publication Date
Jan 01, 1998
Volume
47
Issue
1
Pages
57–62
Identifiers
PMID: 9493976
Source
Medline
License
Unknown

Abstract

MDA-468 human breast cancer cells overexpress the EGFR and exhibit a functional TGFalpha-EGFR autocrine pathway. Loss of EGFR expression following stable transfection with an antisense EGFR cDNA containing plasmid down-regulates type I cAMP-dependent protein kinase (PKAI) expression with acquisition of cell growth resistance to the PKAI inhibitor 8-Cl-cAMP. These results suggest that PKAI expression and function are controlled by a TGFalpha-EGFR autocrine pathway in human breast cancer cells overexpressing the EGFR.

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