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Double transformation of a hematopoietic malignancy and severe associated thrombopathy. Case presentation and review of the literature.

Authors
  • Cişleanu, Diana
  • Onisâi, Minodora
  • Vlădăreanu, Ana-Maria
  • Găman, Mihaela
  • Neagul, Ana-Maria
  • Bumbea, H
  • Iova, Anamaria
  • Baluţa, Cristina
  • Cazaceanu, Oana
  • Begu, Mădălina
  • Ilea, Anca
Type
Published Article
Journal
Romanian journal of internal medicine = Revue roumaine de médecine interne
Publication Date
Jan 01, 2011
Volume
49
Issue
2
Pages
137–144
Identifiers
PMID: 22303605
Source
Medline
License
Unknown

Abstract

We present the case of a patient with a double transformation during the evolution of chronic hematopoietic malignancy - JAK2 positive chronic myeloproliferative neoplasm; the first transformation had occurred previous to the presentation in our Department, but the second transformation was observed in evolution and it was into a rapidly evolving disease, followed by survival of less than one month. We underline the very poor prognosis -- overall survival of 2.5 years from initial presentation -- a much reduced survival for a chronic myeloproliferative neoplasm, probably due also to multiple associated pathology. Also, the other interesting element of the case is related to the dysfunctional platelets -- hemorrhagic complication at increased platelet count, respectively thrombosis at platelet count under 20000/mmc.

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