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Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic.

Authors
  • Dire, D J
  • Hogan, D E
Type
Published Article
Journal
Annals of Emergency Medicine
Publisher
Elsevier
Publication Date
Sep 01, 1993
Volume
22
Issue
9
Pages
1419–1422
Identifiers
PMID: 8363115
Source
Medline
License
Unknown

Abstract

The duration of local anesthesia for 1% lidocaine was significantly longer and the depth of anesthesia after 30 minutes was significantly higher than that of 1% diphenhydramine. Diphenhydramine resulted in skin necrosis in one test subject.

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