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A double blind clinical trial on the efficacy of honey drop in vernal keratoconjunctivitis.

Authors
  • Salehi, Ali
  • Jabarzare, Solmaz
  • Neurmohamadi, Mohammadreza
  • Kheiri, Soleiman
  • Rafieian-Kopaei, Mahmoud
Type
Published Article
Journal
Evidence-based complementary and alternative medicine : eCAM
Publication Date
Jan 01, 2014
Volume
2014
Pages
287540–287540
Identifiers
DOI: 10.1155/2014/287540
PMID: 24707307
Source
Medline
License
Unknown

Abstract

Purpose. This trial was designed to evaluate the efficacy and safety of topical honey eye drops in patients with diagnosed VKC. Methods. This clinical trial was conducted on 60 patients with diagnosed VKC. The patients were selected and randomly allocated between two groups of 30. Patients in two groups received honey eye drop (60% in artificial tear) or placebo, other than cromolyn and fluorometholone 1% eye drops, to be used topically in each eye, four times per day. The patients were examined with slit lamp and torch at baseline and the follow-up visits on the 1st, 3rd, and 6th months of the study for redness, limbal papillae, and intraocular pressure. Results. Out of 60 patients who completed the study, 19 patients (31.7%) were female. There was significant increase in eye pressure and reduction in redness as well as limbal papillae, following the consumption of the honey drop in honey group compared to placebo control group (P < 0.05). At the end of trial, one patient in honey group and 7 ones in placebo group had limbal papillae (P < 0.05). Conclusion. Topical honey eye drops, when used along with Cromolyn and Fluorometholone eye drops, might be beneficial for the treatment of VKC.

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