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Dose-dependent regulation of high-density lipoprotein metabolism with rosuvastatin in the metabolic syndrome.

Authors
  • Ooi, Esther M M
  • Watts, Gerald F
  • Nestel, Paul J
  • Sviridov, Dmitri
  • Hoang, Anh
  • Barrett, P Hugh R
Type
Published Article
Journal
The Journal of clinical endocrinology and metabolism
Publication Date
Feb 01, 2008
Volume
93
Issue
2
Pages
430–437
Identifiers
PMID: 18029469
Source
Medline
License
Unknown

Abstract

Rosuvastatin dose-dependently increased plasma HDL cholesterol and LpA-I concentrations in the metabolic syndrome. This could relate to reduction in plasma triglycerides with remodeling of HDL particles and reduction in LpA-I fractional catabolism. The findings contribute to understanding mechanisms for the HDL-raising effect of rosuvastatin in the metabolic syndrome with implications for reduction in cardiovascular disease.

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