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Dorsal facial area of cat medulla; 5-HT2 action on glutamate release in regulating common carotid blood flow.

Authors
  • Kuo, J S
  • Li, H T
  • Lin, N N
  • Yang, C S
  • Cheng, F C
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
May 07, 1999
Volume
266
Issue
2
Pages
137–140
Identifiers
PMID: 10353346
Source
Medline
License
Unknown

Abstract

Serotonin (5-HT) may inhibit glutamate release in the dorsal facial area (DFA) of the medulla and decrease common carotid arterial (CCA) blood flow. We attempted to clarify which subtype(s) of 5-HT receptor was involved. A microdialysis probe was inserted in DFA. The concentration of glutamate in dialysates were determined by chromatography. Glutamate concentration was dose-dependently decreased by perfusion of 5-HT or DOI, a 5-HT2 agonist, but not by 5-CT, a 5-HT1 agonist. The 5-HT-induced decrease in glutamate was reversed by co-perfusion of ketanserin, a 5-HT2 antagonist, but not by propranolol, a 5-HT1 antagonist. CCA blood flow was decreased when 5-HT or DOI was perfused, and was reversed by co-perfusing ketanserin. In conclusion, 5-HT may inhibit glutamate release via 5-HT2 receptor in DFA, resulting in the reduction of CCA blood flow.

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