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Doping β-TCP as a Strategy for Enhancing the Regenerative Potential of Composite β-TCP—Alkali-Free Bioactive Glass Bone Grafts. Experimental Study in Rats

Authors
  • Ferreira, Manuel M.
  • Brito, Ana F.
  • Brazete, Daniela
  • Pereira, Inês C.
  • Carrilho, Eunice
  • Abrantes, Ana M.
  • Pires, Ana S.
  • Aguiar, Maria J.
  • Carvalho, Lina
  • Botelho, Maria F.
  • Ferreira, José M.F.
Publication Date
Dec 20, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

-TCP and an alkali-free bioactive glass were prepared and implanted in ~4 mm diameter bone defects drilled in the calvaria of Wistar rats used as animal models. The animals were sacrificed after 9 weeks of implantation and the calvaria was excised. Non-manipulated bone was used as positive control, while empty defects were used as a negative control group. The von Kossa staining revealed an enhanced new bone formation with increasing doping levels, supporting the therapeutic effects exerted by the doping elements. The percentage of newly formed bone was similar when the defects were filled with autologous bone, BG (previous results) or 3TCP2/7BG, which indicates that the latter two are excellent candidates for replacement of autologous bone as bone regeneration material. This finding confirms that doping with suitable doses of therapeutic ions is a good strategy towards transposing the bone graft materials to biomedical applications in humans.

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