Affordable Access

Dopamine receptors on isolated membranes of rat thymocytes.

Authors
  • Ovadia, H
  • Lubetzki-Korn, I
  • Abramsky, O
Type
Published Article
Journal
Annals of the New York Academy of Sciences
Publication Date
Jan 01, 1987
Volume
496
Pages
211–216
Identifiers
PMID: 3496824
Source
Medline
License
Unknown

Abstract

Using [3H]DA as the ligand of choice, we have shown that rat thymocytes possess dopamine binding sites. The binding of [3H]DA was specific, saturable and of high affinity. [3H]DA binding was rapid and reversible; [3H]DA was totally displaced by low concentrations of dopamine, norepinephrine, and apomorphine. The binding sites were insensitive to neuroleptic drugs such as sulpiride, bromocriptine, and haloperidol. On the basis of these findings, we have suggested that thymocytes possess a D-3 receptor type.

Report this publication

Statistics

Seen <100 times