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Donor safety in live-related liver transplantation.

Authors
  • Wakade, V A1
  • Mathur, S K
  • 1 Department of Surgical Gastroenterology and Liver Transplantation, Fortis Hospital, Mulund Goregaon Link Road, Bhandup West, Mumbai, 400078 India. , (India)
Type
Published Article
Journal
The Indian journal of surgery
Publication Date
Feb 01, 2012
Volume
74
Issue
1
Pages
118–126
Identifiers
DOI: 10.1007/s12262-011-0385-4
PMID: 23372315
Source
Medline
Keywords
License
Unknown

Abstract

Living donor liver transplantation (LDLT), since its advent in late 1980's and early 1990's, has rapidly increased especially in countries like Japan, Korea and India where cadaveric programmes are not as well established as in the western world. The main advantage of LDLT is the availability of an organ in the elective setting in the course of a progressive liver disease. This is most applicable in patients with Cirrhosis and Hepatocellular carcinoma. LDLT, from the donor's perspective does carry a risk of not only morbidity but mortality. To date the surgical mortality risk is estimated at 0.1% for left lateral donation and 0.5% for right liver donation. Donor mortality has been reported from various centres in India. There are reports of complications like Hepatic artery thrombosis, portal vein thrombosis and especially biliary leaks and strictures occurring at a significantly increased frequency after living as compared to deceased donor liver transplantation. The key to reduce donor morbidity and mortality is meticulous donor selection and thorough donor work up. In the present study we will analyse the factors that contributed to donor mortality and morbidity and prepare a detailed work up plan, intraoperative and post-operative strategy to reduce donor morbidity and mortality.

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