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Donor lungs with pulmonary embolism evaluated with ex vivo lung perfusion.

Authors
  • Brown, Chase R
  • Brozzi, Nicolas A
  • Vakil, Nakul
  • Shafii, Alexis E
  • Murthy, Sudish C
  • Pettersson, Gosta B
  • Mason, David P
Type
Published Article
Journal
ASAIO Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jan 01, 2012
Volume
58
Issue
4
Pages
432–434
Identifiers
DOI: 10.1097/MAT.0b013e318251cde4
PMID: 22588145
Source
Medline
License
Unknown

Abstract

Acute pulmonary embolism (PE) compromises oxygenation and is typically considered a contraindication to lung donation for transplantation. We report the use of ex vivo lung perfusion (EVLP) to evaluate and possibly improve a pair of donor lungs with PE and poor oxygen exchange to a condition that might have been suitable for subsequent transplantation. A pair of donor lungs was procured for research after being declined for clinical use and placed on the EVLP circuit for 7 hours. Functional monitoring of the lungs revealed an increase in the partial pressure of oxygen to fraction of inspired oxygen ratio (P/F ratio) from 268 in situ to 458 after EVLP. While on the circuit, pulmonary vascular resistance decreased as dynamic compliance of the lungs increased, suggesting they might have been acceptable for transplantation.

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